If you have been feeling persistently down, anxious, or emotionally flat and cannot quite explain why, your hormones may be part of the answer. Many men dealing with depression and anxiety never consider that a hormonal imbalance could be contributing to how they feel. TRT for depression and anxiety in men is a topic that does not get nearly enough attention, yet the connection between testosterone deficiency and mood is one of the most well-documented and most overlooked areas in men’s health.